Chemistry
Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.
Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.
Recent Grants include:
- Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
- Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
- Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
- Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”
Submissions from 2019
Approximating dynamic proximity with a hybrid geometry energy-based kernel for diffusion maps, Qingzhe Tan, Mojie Duan, Minghai Li, Li Han, and Shuanghong Huo
Bitumen's microstructures are correlated with its bulk thermal and rheological properties, Xiaokong Yu, Nancy A. Burnham, Sergio Granados-Focil, and Mingjiang Tao
Inhibition of the self-assembly of Aβ and of tau by polyphenols: Mechanistic studies, Qiuchen Zheng, Micheal T. Kebede, Merc M. Kemeh, Saadman Islam, Bethany Lee, Stuart D. Bleck, Liliana A. Wurfl, and Noel D. Lazo
Submissions from 2018
Bifunctional Molecular Probes for Activity-Based Visualization of Quinone-Dependent Amine Oxidases, Ashley A. Burke, Luke Barrows, Maria J. Solares, Alexander D. Wall, and Charles E. Jakobsche
Communication—sulfonated poly (ether ether ketone) as cation exchange membrane for alkaline redox flow batteries, D. De Porcellinis, B. Mecheri, A. D’Epifanio, S. Licoccia, S. Granados-Focil, and M. J. Aziz
A numerical study of adaptive building enclosure systems using solid–solid phase change materials with variable transparency, Gert Guldentops, Giuseppe Ardito, Mingjiang Tao, Sergio Granados-Focil, and Steven Van Dessel
Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme, Valerie A. Ivancic, Claire A. Krasinski, Qiuchen Zheng, Rebecca J. Meservier, Donald E. Spratt, and Noel D. Lazo
Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42, Claire A. Krasinski, Valerie A. Ivancic, Qiuchen Zheng, Donald E. Spratt, and Noel D. Lazo
The Longest Amyloid-β Precursor Protein Intracellular Domain Produced with Aβ42 Forms β-Sheet-Containing Monomers That Self-Assemble and Are Proteolyzed by Insulin-Degrading Enzyme, Claire A. Krasinski, Qiuchen Zheng, Valerie A. Ivancic, Donald E. Spratt, and Noel D. Lazo
Cellulase-Inspired Solid Acids for Cellulose Hydrolysis: Structural Explanations for High Catalytic Activity, Maksim Tyufekchiev, Pu Duan, Klaus Schmidt-Rohr, Sergio Granados Focil, Michael T. Timko, and Marion H. Emmert
Time- and Composition-Dependent Evolution of Distinctive Microstructures in Bitumen, Xiaokong Yu, Sergio Granados-Focil, Mingjiang Tao, and Nancy A. Burnham
Reaction kinetics of red mud-fly ash based geopolymers: Effects of curing temperature on chemical bonding, porosity, and mechanical strength, Mo Zhang, Mengxuan Zhao, Guoping Zhang, Jennifer M. Sietins, Sergio Granados-Focil, Marc S. Pepi, Yan Xu, and Mingjiang Tao
Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid, Qiuchen Zheng and Noel D. Lazo
Submissions from 2017
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases, Ashley A. Burke, Elizabeth S. Severson, Shreya Mool, Maria J. Solares Bucaro, Frederick T. Greenaway, and Charles E. Jakobsche
Review on solid-solid phase change materials for thermal energy storage: Molecular structure and thermal properties, Ali Fallahi, Gert Guldentops, Mingjiang Tao, Sergio Granados-Focil, and Steven Van Dessel
A versatile platform for adding functional properties to amyloid fibrils, Devon F.A. Fontaine, Valerie A. Ivancic, Michael B. Reardon, Noel D. Lazo, and Charles E. Jakobsche
Observations on AMBER force field performance under the conditions of low pH and high salt concentrations, Hanzhong Liu, Qingzhe Tan, Li Han, and Shuanghong Huo
Thermoreversible ion gels from side-chain liquid crystalline brushes diblock copolymers, Chi Thanh Nguyen, Prashant Deshmukh, Xiaorui Chen, Sergio Granados-Focil, and Rajeswari M. Kasi
Crystal structure of tetraaquabis(pyrimidin-1-ium-4,6-diolato-κO4)manganese(II), Khaled A. Shennara, Ray J. Butcher, and Frederick T. Greenaway
Bistability in Organic Magnetic Materials: A Comparative Study of the Key Differences between Hysteretic and Non-hysteretic Spin Transitions in Dithiazolyl Radicals, Sergi Vela, Michael B. Reardon, Charles E. Jakobsche, Mark M. Turnbull, Jordi Ribas-Arino, and Juan J. Novoa
Ring opening metathesis polymerization of triazole-bearing cyclobutenes: Diblock copolymer synthesis and evaluation of the effect of side group size on polymerization kinetics, Jia Wei, William Trout, Yoan C. Simon, and Sergio Granados-Focil
Submissions from 2016
Inherent structure versus geometric metric for state space discretization, Hanzhong Liu, Minghai Li, Jue Fan, and Shuanghong Huo
A simple synthesis of 6-hydroxynorleucine based on the rearrangement of an N-nitrosodichloroacetamide, Blaine G. McCarthy, Nicholas S. Macarthur, and Charles E. Jakobsche
Simple, Robust, and Plasticizer-Free Iodide-Selective Sensor Based on Copolymerized Triazole-Based Ionic Liquid, Lukasz Mendecki, Xiaorui Chen, Nicole Callan, David F. Thompson, Benjamin Schazmann, Sergio Granados-Focil, and Aleksandar Radu
Long-Range Reactivity Modulations in Geranyl Chloride Derivatives, Michael B. Reardon, Muyun Xu, Qingzhe Tan, P. George Baumgartel, Danielle J. Augur, Shuanghong Huo, and Charles E. Jakobsche
