Chemistry
Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.
Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.
Recent Grants include:
- Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
- Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
- Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
- Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”
Submissions from 2023
Tetrahalidocuprate(II) complexes with substituted pyridinium ions: effects of halide substitution, Lixin Li, Alexander Shapiro, Firas F. Awwadi, Christopher P. Landee, Mark M. Turnbull, and Jan L. Wikaira
Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions, Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A. Goddard, and James R. Heath
μ-1,6-Dioxo-1,6-diphenylhexane-3,4-diolato-bis[(2,2′-bipyridine)chloridocopper(II)] dihydrate a; b; a, Luke Nye, Shane G. Tefler, and Mark M. Turnbull
Field-Tunable Berezinskii-Kosterlitz-Thouless Correlations in a Heisenberg Magnet, D. Opherden, M.S.J. Tepaske, F. Bärtl, M. Weber, M.M Turnbull, T. Lancaster, S.J. Blundell, M. Baenitz, J. Wosnitza, C.P. Landee, R. Moessner, and D.J. Luitz
Linear Mn(II)4Ln(III)2 (Ln = Gd, Dy, Tb) heterometallic complexes from a ditopic hydrazone ligand: Slow magnetic relaxation in Mn4Dy2 complex, Azeem Shakeel, Hamed Bakhshi, Touqeer Ahmed, Lara Watanabe, Mark Turnbull, Ahmed Al-Harrasi, and Muhammad U. Anwar
Structural properties of optically clear bacterial cellulose produced by Komagataeibacter hansenii using arabitol, Elizabeth M. van Zyl, Mitchell A. Kennedy, Wendy Nason, Sawyer J. Fenlon, Eric M. Young, Luis J. Smith, Surita R. Bhatia, and Jeannine M. Coburn
Crystal growth, Hirshfeld analysis, thermal behavior and magnetic properties of a new hybrid material (C5H14N2)[MnCl3(H2O)3]Cl, Sandra Walha, Basem F. Ali, Abdellah Kaiba, Mark M. Turnbull, and Thierry Roisnel
Synthesis, Structural, Magnetic and Computational Studies of a One-Dimensional Ferromagnetic Cu(II) Chain Assembled from a New Schiff Base Ligand, Anne Worrell, Gabriele Delle Monache, Mark M. Turnbull, Jeremy M. Rawson, Theocharis C. Stamatatos, and Melanie Pilkington
Challenges and Strategies for Synthesizing Glutamyl Hydrazide Containing Peptides, Muyum Xu, Nicholas S. MacArthur, Chau Minh Duong, Saadman Islam, Joseph P. McElwee, and Charles E. Jakobsche
Submissions from 2022
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A, Munawar Ayesha, Abbasi Majid, Dongting Zhao, Frederick T. Greenaway, Naimeng Yan, Qinlong Liu, Shuqing Liu, and Ming Zhong Sun
Binding Characterization of Cyclic Peptide Ligands to Target Proteins and Chemical Epitopes Using ELISA and Fluorescence Polarization Assays, Ariane Borges, Iryna Onasenko, and Arundhati Nag
A novel passive polymer-sorbent thermal battery for low-temperature energy applications: A numerical feasibility study, Jihan El Ouaragli, Zhiying Xiao, Mingjiang Tao, Sergio Granados-Focil, Steven Van Dessel, and Alireza Mahdavi Nejad
Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer, Dipti Kanabar, Mimansa Goyal, Emma I. Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, and Aaron Muth
Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family, Emma I. Kane, Steven A. Beasley, Johanna M. Schafer, Justine E. Bohl, Young Sun Lee, Kayla J. Rich, Elizabeth F. Bosia, and Donald E. Spratt
Contrasting solution-state properties within a family of amyloid-binding molecular tools, Anh Vy Le, Muyun Xu, Tianyi Yang, Luke Barrows, Devon F.A. Fontaine, Shuanghong Huo, and Charles E. Jakobsche
Biomolecular Effects of Dance and Dance/Movement Therapy: A Review, Ivana Lopez-Nieves and Charles E. Jakobsche
Dynamics and allosteric information pathways of unphosphorylated c-Cbl, Tianyi Yang, Li Han, and Shuanghong Huo
Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes, Qiuchen Zheng, Bethany Lee, Micheal T. Kebede, Valerie A. Ivancic, Merc M. Kemeh, Henrique Lemos Brito, Donald E. Spratt, and Noel D. Lazo
Submissions from 2021
Metal oxide supported Ni-impregnated bifunctional catalysts for controlling char formation and maximizing energy recovery during catalytic hydrothermal liquefaction of food waste, Feng Cheng, Geoffrey A. Tompsett, Daniela Valeska Fraga Alvarez, Carla I. Romo, Amy M. McKenna, Sydney F. Niles, Robert K. Nelson, Christopher M. Reddy, Sergio Granados-Fócil, Alex D. Paulsen, Ruihan Zhang, and Michael T. Timko
CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt, Chunmei Guo, Chao Gao, Xinxin Lv, Dongting Zhao, Frederick T. Greenaway, Lihong Hao, Yuxiang Tian, Shuqing Liu, and Ming Zhong Sun
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways, Chunmei Guo, Nannan Li, Chengyong Dong, Liming Wang, Zhaopeng Li, Qinlong Liu, Qinglai Ma, Frederick T. Greenaway, Yuxiang Tian, Lihong Hao, Shuqing Liu, and Ming Zhong Sun
Copper-ligand clusters dictate size of cyclized peptide formed during alkyne-azide cycloaddition on solid support, Rene Kandler, Samir Das, and Arundhati Nag
Structural insights into ankyrin repeat-containing proteins and their influence in ubiquitylation, Emma I. Kane and Donald E. Spratt
Intersection of redox chemistry and ubiquitylation: Post-translational modifications required for maintaining cellular homeostasis and neuroprotection, Emma I. Kane, Kelly L. Waters, and Donald E. Spratt
Mechanistic Insights into Fe Catalyzed α-C−H Oxidations of Tertiary Amines, Christopher J. Legacy, Taylor O. Hope, Yohann Gagné, Frederick T. Greenaway, Mathieu Frenette, and Marion H. Emmert
