Chemistry
Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.
Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.
Recent Grants include:
- Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
- Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
- Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
- Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”
Submissions from 2007
93Nb solid state NMR of high surface area niobium oxides, Luis J. Smith and Wang Xuefeng
Temperature-dependent probabilistic roadmap algorithm for calculating variationally optimized conformational transition pathways, Haijun Yang, Hao Wu, Dawei Li, Li Han, and Shuanghong Huo
Submissions from 2006
Site-selective QPASS for the isolation of large quadrupolar coupling environments, Luis J. Smith and Christopher Seith
Peptide plane can flip in two opposite directions: Implication in amyloid formation of transthyretin, Mingfeng Yang, Ming Lei, Boyan Yordanov, and Shuanghong Huo
The sequence-dependent unfolding pathway plays a critical role in the amyloidogenicity of transthyretin, Mingfeng Yang, Boyan Yordanov, Yaakov Levy, Rafael Brüschweiler, and Shuanghong Huo
Potential influence of Asp in the Ca2+ coordination position 5 of parvalbumin on the calcium-binding affinity: A computational study, Jingyan Zhao, Donald J. Nelson, and Shuanghong Huo
Submissions from 2005
Initial conformational changes of human transthyretin under partially denaturing conditions, Mingfeng Yang, Ming Lei, Rafael Bruschweiler, and Shuanghong Huo
Submissions from 2004
Intrinsic versus mutation dependent instability/flexibility: A comparative analysis of the structure and dynamics of wild-type transthyretin and its pathogenic variants, Ming Lei, Mingfeng Yang, and Shuanghong Huo
