Chemistry
Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.
Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.
Recent Grants include:
- Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
- Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
- Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
- Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”
Submissions from 2012
Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix, Samuel Sparks, Gai Liu, Kevin J. Robbins, and Noel D. Lazo
Submissions from 2011
Identification of the disulfide bonds of lysyl oxidase, Xi Chen and Frederick T. Greenaway
Observation of two families of folding pathways of BBL, Jue Fan, Mojie Duan, Da Wei Li, Hao Wu, Haijun Yang, Li Han, and Shuanghong Huo
Synthesis and characterization of triazolium iodide ionic liquid electrolyte for dye sensitized solar cells, Akshay Kokil, Alfonso Renna, Jayant Kumar, and Sergio Granados-Focil
Identification of the copper-binding ligands of lysyl oxidase, Karlo M. Lopez and Frederick T. Greenaway
Detection of strongly bound thioflavin T species in amyloid fibrils by ligand-detected 1H NMR, Kevin J. Robbins, Gai Liu, Guoxing Lin, and Noel D. Lazo
From computational discovery to experimental characterization of a high hole mobility organic crystal, Anatoliy N. Sokolov, Sule Atahan-Evrenk, Rajib Mondal, Hylke B. Akkerman, Roel S. Sánchez-Carrera, Sergio Granados-Focil, Joshua Schrier, Stefan C.B. Mannsfeld, Arjan P. Zoombelt, Zhenan Bao, and Alán Aspuru-Guzik
Submissions from 2010
Triazole functionalized sol-gel membranes, effect of crosslink density and heterocycle content on water free proton conduction and membrane mechanical properties, Sergio Granados-focil, J. R. Conway, Y. Meng, and L. J. Smith
Purification of high yields of catalytically active lysyl oxidase directly from Escherichia coli cell culture, Sanna E. Herwald, Frederick T. Greenaway, and Karlo M. Lopez
Rigid rod polyelectrolytes with frozen-in free volume: High conductivity at low RH, Morton Lift, Sergio Granados-Focil, and Junwon Kang
Rigid rod poly(p-phenylene sulfonic acid) PEMs: High conductivity at low relative humidity due to "frozen-in-free volume", Morton Litt, Sergio Granados-Focil, Junwon Kang, Kun Si, and Ryszard Wycisk
Mechanistic studies of peptide self-assembly: Transient α-helices to stable β-sheets, Gai Liu, Anabathula Prabhakar, Darryl Aucoin, Miranda Simon, Samuel Sparks, Kevin J. Robbins, Andrew Sheen, Sarah A. Petty, and Noel D. Lazo
A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality, Shuqing Liu, Yuxiang Tian, Frederick T. Greenaway, and Ming Zhong Sun
Submissions from 2009
1H Solid-State NMR Investigation of Structure and Dynamics of Anhydrous Proton Conducting Triazole-Functionalized Siloxane Polymers, Ümit Akbey, Sergio Granados-Focil, E. Bryan Coughlin, Robert Graf, and Hans Wolfgang Spiess
Amyloid-β 2 protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease, Summer L. Bernstein, Nicholas F. Dupuis, Noel D. Lazo, Thomas Wyttenbach, Margaret M. Condron, Gal Bitan, David B. Teplow, Joan Emma Shea, Brandon T. Ruotolo, Carol V. Robinson, and Michael T. Bowers
An investigation of distortions of the dion-jacobson phase RbSr 2Nb 3O 10 and its acid-exchanged form with 93Nb solid state NMR and DFT calculations, Xuefeng Wang, Jhashanath Adhikari, and Luis J. Smith
Incomplete double frequency sweeps to select small quadrupolar coupling static powder patterns, Xuefeng Wang and Luis J. Smith
Submissions from 2008
Effects of Familial Alzheimer's Disease Mutations on the Folding Nucleation of the Amyloid β-Protein, Mary Griffin Krone, Andrij Baumketner, Summer L. Bernstein, Thomas Wyttenbach, Noel D. Lazo, David B. Teplow, Michael T. Bowers, and Joan Emma Shea
Formation and growth of oligomers: A monte carlo study of an amyloid tau fragment, Da Wei Li, Sandipan Mohanty, Anders Irbäck, and Shuanghong Huo
Predicting the folding pathway of engrailed homeodomain with a probabilistic roadmap enhanced reaction-path algorithm, Da Wei Li, Haijun Yang, Li Han, and Shuanghong Huo
A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility, Chee Chew Lim, Haijun Yang, Mingfeng Yang, Chien Kao Wang, Jianru Shi, Eric A. Berg, David R. Pimentel, Judith K. Gwathmey, Roger J. Hajjar, Michiel Helmes, Catherine E. Costello, Shuanghong Huo, and Ronglih Liao
Solid-state NMR strategies for characterizing high surface area niobates, Xuefeng Wang and Luis J. Smith
Submissions from 2007
Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus, Marianne A. Grant, Noel D. Lazo, Aleksey Lomakin, Margaret M. Condron, Hiromi Arai, Ghiam Yamin, Alan C. Rigby, and David B. Teplow
Structural and pathway complexity of β-strand reorganization within aggregates of human transthyretin(105-115) peptide, Da Wei Li, Li Han, and Shuanghong Huo
Evaluation of configurational entropy methods from peptide folding-unfolding simulation, Da Wei Li, Mina Khanlarzadeh, Jinbu Wang, Shuanghong Huo, and Rafael Brüschweiler
