Chemistry
Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.
Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.
Recent Grants include:
- Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
- Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
- Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
- Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”
Submissions from 2021
The potential role of miR-124-3p in tumorigenesis and other related diseases, Qian Li, Shuqing Liu, Jinsong Yan, Ming Zhong Sun, and Frederick T. Greenaway
Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response, Nicholas A. Mathieu, Rafael H. Levin, and Donald E. Spratt
Herc5 and the isgylation pathway: Critical modulators of the antiviral immune response, Nicholas A. Mathieu, Ermela Paparisto, Stephen D. Barr, and Donald E. Spratt
Fluorescent Sensors of Phosphate Containing Biomolecules, Arundhati Nag and Samir Das
Interplay between human islet amyloid polypeptide aggregates and micro-heterogeneous membranes, Qingzhe Tan, Hanzhong Liu, Mojie Duan, and Shuanghong Huo
Thermal optimization of a novel thermo-optically responsive SS-PCM coatings for building enclosures, Zhiying Xiao, Pramod Mishra, Alireza Mahdavi Nejad, Mingjiang Tao, Sergio Granados-Focil, and Steven Van Dessel
Rational design of solid-acid catalysts for cellulose hydrolysis using colloidal theory, Ziyang Zhang, Geoffrey A. Tompsett, Sergio Granados-Focil, Christopher R. Lambert, and Michael T. Timko
Differential effects of polyphenols on insulin proteolysis by the insulin-degrading enzyme, Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, and Noel Lazo
Submissions from 2020
An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity, Steven A. Beasley, Chloe E. Kellum, Rachel J. Orlomoski, Feston Idrizi, and Donald E. Spratt
Bioinspired building envelopes, Steven Dessel, Mingjiang Tao, and Sergio Granados-Focil
Establishing Meaningful Limits of Detection for Ion-Selective Electrodes and Other Nonlinear Sensors, Peter W. Dillingham, Basim S.O. Alsaedi, Sergio Granados-Focil, Aleksandar Radu, and Christina M. McGraw
A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma, Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu, and Ming Zhong Sun
Quantification of Surface Reactivity and Step-Selective Etching Chemistry on Single-Crystal BiOI(001), Julia L. Martin, Roy Stoflet, Alexander D. Carl, Katarina M. Himmelberger, Sergio Granados-Fócil, and Ronald L. Grimm
Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits, Lukasz Mendecki, Sergio Granados-Focil, Martin Jendrlin, Matthew Mold, and Aleksandar Radu
Interfacial states, energetics, and atmospheric stability of large-grain antifluorite Cs2TiBr6, Jocelyn L. Mendes, Weiran Gao, Julia L. Martin, Alexander D. Carl, N. Aaron Deskins, Sergio Granados-Focil, and Ronald L. Grimm
Thermo-optically responsive phase change materials for passive temperature regulation, Pramod Mishra, Kelli Stockmal, Giuseppe Ardito, Mingjiang Tao, Steven Van Dessel, and Sergio Granados-Focil
Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP, Lena K. Ries, Anna K.L. Liess, Christian G. Feiler, Donald E. Spratt, Edward D. Lowe, and Sonja Lorenz
HECT E3 ubiquitin ligases - Emerging insights into their biological roles and disease relevance, Yaya Wang, Diana Argiles-Castillo, Emma I. Kane, Anning Zhou, and Donald E. Spratt
Strategies for extending zeolite stability in supercritical water using thermally stable coatings, Yuanpu Wang, Patricia Guerra, Azadeh Zaker, Alex R. Maag, Geoffrey A. Tompsett, Luis J. Smith, Xinlei Huang, Jesse Q. Bond, and Michael T. Timko
Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides, Qiuchen Zheng, Senegal N. Carty, and Noel D. Lazo
Submissions from 2019
1 H, 13 C, and 15 N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH, Steven A. Beasley, Roela Bardhi, and Donald E. Spratt
Biological applications of amide and amino acid containing synthetic macrocycles, Ariane Borges, Dylan Gillespie, and Arundhati Nag
Non-corrosive, low-toxicity gel-based microbattery from organic and organometallic molecules, Frank N. Crespilho, Graziela C. Sedenho, Diana De Porcellinis, Emily Kerr, Sergio Granados-Focil, Roy G. Gordon, and Michael J. Aziz
Development of Bifunctional Hydrodeoxygenation Catalyst Rh-HY for the Generation of Biomass-Derived High-Energy-Density Fuels, Andrés A. Granados Fócil, Sergio Granados Fócil, Víctor M. Conde Sotelo, Ronald Lionel Grimm, Federico González García, Eleazar Rojas Santiago, Carlos E. Santolalla Vargas, Marco A. Vera Ramírez, and José Antonio de los Reyes Heredia
ZSM-5 decrystallization and dealumination in hot liquid water, Alex R. Maag, Geoffrey A. Tompsett, Jason Tam, Cheen Aik Ang, Gisele Azimi, Alexander D. Carl, Xinlei Huang, Luis J. Smith, Ronald L. Grimm, Jesse Q. Bond, and Michael T. Timko
