Chemistry
Document Type
Article
Abstract
Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1–E2–E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5 (HERC5) regulates ISG15 signaling in response to hepatitis C (HCV), influenza-A (IAV), human immunodeficiency virus (HIV), SARS-CoV-2 and other viral infections. Taken together, the potent antiviral activity displayed by HERC5 and ISG15 make them promising drug targets for the development of novel antiviral therapeutics that can augment the host antiviral response. In this review, we examine the emerging role of ISG15 in antiviral immunity with a particular focus on how HERC5 orchestrates the specific and timely ISGylation of viral proteins in response to infection.
Publication Title
Viruses
Publication Date
6-2021
Volume
13
Issue
6
ISSN
1999-4915
DOI
10.3390/v13061102
Keywords
Antiviral immune response, HECT E3 ubiquitin ligase, HERC5, Interferon, ISG15, ISGylation
Repository Citation
Mathieu, Nicholas A.; Paparisto, Ermela; Barr, Stephen D.; and Spratt, Donald E., "Herc5 and the isgylation pathway: Critical modulators of the antiviral immune response" (2021). Chemistry. 143.
https://commons.clarku.edu/chemistry/143
Cross Post Location
Student Publications
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Conditions
Mathieu, N. A., Paparisto, E., Barr, S. D., & Spratt, D. E. (2021). HERC5 and the ISGylation pathway: critical modulators of the antiviral immune response. Viruses, 13(6), 1102.
