Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation

Authors

Mansoura Bourwina, Universite de Sfax
Sandra Walha, Universite de Sfax
Najeh Krayem, Universite de Sfax
Riadh Badraoui, University of Tunis El Manar
Faten Brahmi, University of Ha'il
Mark M. Turnbull, Clark UniversityFollow
Wejdan M. Alshammari, University of Ha'il
Mejdi Snoussi, University of Ha'il
Thierry Roisnel, Institut des Sciences Chimiques de Rennes
Houcine Naïli, Universite de Sfax

Document Type

Article

Abstract

A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C₅H₁₄N₂)[MnCl₄(H₂O)₂] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl₄(H₂O)₂]²⁻. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses. © 2023 by the authors.

This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application

Publication Title

Inorganics

Publication Date

2-2023

Volume

11

Issue

2

ISSN

2304-6740

DOI

10.3390/inorganics11020076

Keywords

biological activity, infrared spectroscopy, magnetic properties, manganese (II) complex, optical band gap, pharmacokinetics, thermal analysis

Repository Citation

Bourwina, Mansoura; Walha, Sandra; Krayem, Najeh; Badraoui, Riadh; Brahmi, Faten; Turnbull, Mark M.; Alshammari, Wejdan M.; Snoussi, Mejdi; Roisnel, Thierry; and Naïli, Houcine, "Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation" (2023). Chemistry. 4.
https://commons.clarku.edu/chemistry/4

Creative Commons License

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