Chemistry

Biological applications of amide and amino acid containing synthetic macrocycles

Document Type

Article

Abstract

Amino acid derived macrocycles with elaborate well-defined stereochemistry are a unique class of compounds that have been isolated from natural sources. Macrocycles like cyclosporine, octreotide, and valinomycin have been used in multiple applications, like drugs or ion sensors. Chemists have long been fascinated by the unique molecular recognition capabilities of these macrocycles and tried to design synthetic analogs with similar functions. This article is focused on reviewing current research on amide and amino acid containing macrocycles that have been developed in research laboratories for biological recognition, specifically for anion sensing, ion transport, carbohydrate sensing, and peptide sensing.

Publication Title

Supramolecular Chemistry

Publication Date

8-3-2019

Volume

31

Issue

8

First Page

575

Last Page

596

ISSN

1061-0278

DOI

10.1080/10610278.2019.1650178

Keywords

carbohydrate, cyclic peptide, ion transport, Macrocycles, phosphate sensing

Cross Post Location

Student Publications

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