Chemistry

 

Chemistry and Biochemistry

Our accomplished faculty serves in editorial positions with the Journal of Coordination Chemistry, Journal of Medicinal Chemistry and Drug Design, and European Chemical Bulletin, among others.

Several hold patents developed through their research, and are members and fellows of the American Chemical Society. Their impactful research on health- and materials-related chemistry contributes to answering some of society’s most pressing scientific questions.

Recent Grants include:

  • Sergio Granados-Focil and Luis Smith, National Science Foundation: “An integrated study of ion dynamics and population distributions to understand the molecular underpinnings of charge transport through self-assembled solid polymer electrolytes”
  • Noel Lazo, National Institutes of Health (National Institute on Aging): “Determinants of the Proteolytic Degradation of Soluble Amyloid-beta”
  • Sergio Granados-Focil, in collaboration with Steven Van Dessel of WPI’s Civil Engineering Department, National Science Foundation: “Collaborative Research: Adaptive Building Enclosure Systems Using Cellular Solid-Solid Phase Change Materials With Variable Transparency”
  • Donald Spratt, National Institutes of Health (National Institute of General Medical Sciences): “Structure and Mechanism of HECT E3 Ubiquitin Ligases”

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Submissions from 2024

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Synthesis and evaluation of 2,5-substituted pyrimidines as small-molecule gankyrin binders, Dipti Kanabar, Emma I. Kane, Tejashri Chavan, Taylor M. Laflamme, Ethan Suarez, Mimansa Goyal, Vivek Gupta, Donald E. Spratt, and Aaron Muth

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Highly toxic Aβ begets more Aβ, Merc M. Kemeh and Noel Lazo

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A perspective on the stimuli-responsive photoactivities of coumarin with a focus on redox-responsive photodynamic therapy (PDT), Vineeth M. Pillai, M.M. Sreejaya, Ajula C P, Haridev M., Anju Murali, Harikrishnan K K, Manoranjan Bera, and Moumita Gangopadhyay

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New Discoveries on Protein Recruitment and Regulation during the Early Stages of the DNA Damage Response Pathways, Kelly Waters and Donald E. Spratt

Submissions from 2023

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A copper(II) coordination polymer of formate-bridged dimers: an alternating S = ½ antiferromagnetic chain, Anthony W. Addison, Raymond Butcher, and Mark Turnbull

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Pyridyl-imidazole copper compounds, Alma Araujo Martinez, Christopher L. Landee, Diane Dickie, Jan L. Wikaira, Fan Xiao, and Mark M. Turnbull

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A family of methoxide-bridged Cu(II) compounds with N-heterocyclic ligands: dimers and chains, Alma P. Araujo-Martinez, Kesli Faber, Diane A. Dickie, Christopher P. Landee, Mark M. Turnbull, Brendan Twamley, and Nathan Huynh

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Halogen bond and polymorphism in trans-bis(2-iodo-5-halopyridine)dihalocopper(ii) complexes: crystallographic, theoretical and magnetic studies, Firas F. Awwadi, Manal I. Alwahsh, Mark M. Turnbull, and Christopher Landee

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Copper(II) halide salts of 5-bromo-2-aminopyridine and 3,5-dibromo-2-aminopyridine: syntheses, structures and magnetic behavior, Charlotte P. Bedford, Christopher Landee, Mark M. Turnbull, and Jan L. Wikaira

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The odd-even effect in n-carboxyalkylammonium-containing organic-inorganic hybrids of Mn(ii) halides: structural and magnetic characterisation, Shalene N. Bothma, Charles J. Sheppard, Mark M. Turnbull, Christopher P. Landee, and Melanie Rademeyer

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Crystal Chemistry, Optic and Magnetic Characterizations of a New Copper Based Material Templated by Hexahydrodiazepine, Mansoura Bourwina, Rawia Msalmi, Sandra Walha, Mark M. Turnbull, Thierry Roisnel, Ahlem Guesmi, Ammar Houas, Naoufel Ben Hamadi, and Houcine Naïli

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Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation, Mansoura Bourwina, Sandra Walha, Najeh Krayem, Riadh Badraoui, Faten Brahmi, Mark M. Turnbull, Wejdan M. Alshammari, Mejdi Snoussi, Thierry Roisnel, and Houcine Naïli

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Synthesis of copper(II) halide dimers with 2-amino-5-methylpyridine and serendipitous copper catalyzed synthesis of 3-bromo-2-ethyl-5-methyl-1H-pyrrolo[2,3-b]pyridine, Carina L. Chittim, Kesli Faber, Diane A. Dickie, Christopher Landee, Shane G. Telfer, and Mark M. Turnbull

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Satellite ligand effects on magnetic exchange in dimers. A structural, magnetic and theoretical investigation of Cu2L2X4 (L = methylisothiazolinone and X = Cl−, Br−), Stefan Coetzee, Mark M. Turnbull, Christopher Landee, Jeffrey C. Monroe, Mercè Deumal, Juan J. Novoa, and Melanie Rademeyer

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Long-Term Stability of Ferri-/Ferrocyanide as an Electroactive Component for Redox Flow Battery Applications: On the Origin of Apparent Capacity Fade, Eric M. Fell, Diana De Porcellinis, Yan Jing, Valeria Gutierrez-Venegas, Thomas Y. George, Roy G. Gordon, Sergio Granados-focil, and Michael Aziz

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Copper(II) halide complexes of aminopyridines: Synthesis, structure, and magnetic behavior of neutral compounds of 5-IAP: (5-IAP)2CuCl2·H2O, [(5-IAP)2CuBr2]2, (5-IAP)2CuBr2 and (5-IAP)3CuCl2·nH2O (5IAP = 2-amino-5-iodopyridine), Nathan V. Huynh, Lixin Li, Christopher Landee, Louise N. Dawe, Diane A. Dickie, Mark M. Turnbull, and Jan. L. Wikaira

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How to Identify-with as Little as One Question-Students Who Are Likely to Struggle in Undergraduate Organic Chemistry, Charles E. Jakobsche

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Incorporating an Intelligent Tutoring System into the DiscoverOChem Learning Platform, Charles E. Jakobsche, Pitipat Kongsomjit, Conor Milson, Wenxing Wang, and Chun-Kit Ngan

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Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides, Merc M. Kemeh and Noel Lazo

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Tetrahalidocuprate(II) complexes with substituted pyridinium ions: effects of halide substitution, Lixin Li, Alexander Shapiro, Firas F. Awwadi, Christopher P. Landee, Mark M. Turnbull, and Jan L. Wikaira

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Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions, Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A. Goddard, and James R. Heath

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μ-1,6-Dioxo-1,6-diphenylhexane-3,4-diolato-bis[(2,2′-bipyridine)chloridocopper(II)] dihydrate a; b; a, Luke Nye, Shane G. Tefler, and Mark M. Turnbull

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Field-Tunable Berezinskii-Kosterlitz-Thouless Correlations in a Heisenberg Magnet, D. Opherden, M.S.J. Tepaske, F. Bärtl, M. Weber, M.M Turnbull, T. Lancaster, S.J. Blundell, M. Baenitz, J. Wosnitza, C.P. Landee, R. Moessner, and D.J. Luitz

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Linear Mn(II)4Ln(III)2 (Ln = Gd, Dy, Tb) heterometallic complexes from a ditopic hydrazone ligand: Slow magnetic relaxation in Mn4Dy2 complex, Azeem Shakeel, Hamed Bakhshi, Touqeer Ahmed, Lara Watanabe, Mark Turnbull, Ahmed Al-Harrasi, and Muhammad U. Anwar

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Structural properties of optically clear bacterial cellulose produced by Komagataeibacter hansenii using arabitol, Elizabeth M. van Zyl, Mitchell A. Kennedy, Wendy Nason, Sawyer J. Fenlon, Eric M. Young, Luis J. Smith, Surita R. Bhatia, and Jeannine M. Coburn