Chemistry

Document Type

Article

Abstract

Maintaining genomic stability and properly repairing damaged DNA is essential to staying healthy and preserving cellular homeostasis. The five major pathways involved in repairing eukaryotic DNA include base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), non-homologous end joining (NHEJ), and homologous recombination (HR). When these pathways do not properly repair damaged DNA, genomic stability is compromised and can contribute to diseases such as cancer. It is essential that the causes of DNA damage and the consequent repair pathways are fully understood, yet the initial recruitment and regulation of DNA damage response proteins remains unclear. In this review, the causes of DNA damage, the various mechanisms of DNA damage repair, and the current research regarding the early steps of each major pathway were investigated. © 2024 by the authors.

Publication Title

International Journal of Molecular Sciences

Publication Date

2-2024

Volume

25

Issue

3

ISSN

1661-6596

DOI

10.3390/ijms25031676

Keywords

base excision repair, DNA damage, DNA damage response, homologous recombination repair, mismatch repair, non-homologous end joining repair, nucleotide excision repair

Cross Post Location

Student Publications

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Included in

Chemistry Commons

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