Physics
Optimal path to epigenetic switching
Document Type
Article
Abstract
We use large deviation methods to calculate rates of noise-induced transitions between states in multistage genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation. © 2005 The American Physical Society.
Publication Title
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Publication Date
2005
Volume
71
Issue
1
ISSN
1539-3755
DOI
10.1103/PhysRevE.71.011902
Keywords
computer simulation, Eigenvalues and eigenfunctions, matrix algebra, perturbation techniques; Poisson distribution, probability distributions, random processes, signal theory, spurious signal noise
Repository Citation
Roma, David Marin; O'Flanagan, Ruadhan A.; Ruckenstein, Andrei E.; Sengupta, Anirvan M.; and Mukhopadhyay, Ranjan, "Optimal path to epigenetic switching" (2005). Physics. 166.
https://commons.clarku.edu/faculty_physics/166
