Physics
Document Type
Article
Abstract
Are “turn-on” and “turn-off” functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive.
Publication Title
Scientific Reports
Publication Date
12-2020
Volume
10
Issue
1
ISSN
2045-2322
DOI
10.1038/s41598-020-66699-y
Keywords
biochemical reaction networks, biological physics
Repository Citation
Tareen, Ammar; Wingreen, Ned S.; and Mukhopadhyay, Ranjan, "Asymmetry between Activators and Deactivators in Functional Protein Networks" (2020). Physics. 145.
https://commons.clarku.edu/faculty_physics/145
Cross Post Location
Student Publications
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Conditions
Tareen, A., Wingreen, N. S., & Mukhopadhyay, R. (2020). Asymmetry between Activators and Deactivators in functional protein networks. Scientific reports, 10(1), 10131.
