Biology
Document Type
Article
Abstract
Carbonyl sulfide hydrolase (COSase) is a unique enzyme that exhibits high activity towards carbonyl sulfide (COS) but low carbonic anhydrase (CA) activity, despite belonging to the CA family. COSase was initially identified in a sulfur-oxidizing bacterium and later discovered in the ascomycete Trichoderma harzianum strain THIF08. The COSase from T. harzianum has been recognized as a key enzyme in the assimilation of gaseous COS, and homologous genes are widely present not only in Ascomycota but also in Basidiomycota. Here, we characterized the COSases from the basidiomycete Gloeophyllum trabeum NBRC 6430 and T. harzianum to obtain detailed characteristics of fungal COSase. This study contributes to a better understanding of COS metabolism in fungi.
Publication Title
FEBS Letters
Publication Date
2025
ISSN
0014-5793
DOI
10.1002/1873-3468.15098
Keywords
carbonic anhydrase, carbonyl sulfide, carbonyl sulfide hydrolase, fungi, sulfur metabolism
Repository Citation
Iizuka, Ryuka; Ogawa, Takahiro; Tsukida, Rikako; Noguchi, Keiichi; Hibbett, David; Katayama, Yoko; and Yoshida, Makoto, "Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β-carbonic anhydrase" (2025). Biology. 428.
https://commons.clarku.edu/faculty_biology/428
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Conditions
Iizuka, R., Ogawa, T., Tsukida, R., Noguchi, K., Hibbett, D., Katayama, Y., & Yoshida, M. Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase. FEBS letters.