Biology
Epigenetic reprogramming of the genome - From the germ line to the embryo and back again
Document Type
Article
Abstract
Mammalian parental genomes are not functionally equivalent, and both a maternal and paternal contribution is required for normal development. The differences between the parental genomes are the result of genomic imprinting - a form of gene regulation that results in monoallelic expression of imprinted genes. Cis-regulatory elements at imprinted loci are responsible for directing allele-specific epigenetic marks required for correct gene expression. This cis information must be interpreted at various points in development, including in the germline where existing imprints are erased and reset. Imprints must also be maintained during preimplantation development, when the genome undergoes dramatic global epigenetic changes.
Publication Title
International Journal of Developmental Biology
Publication Date
5-29-2001
Volume
45
Issue
3
First Page
533
Last Page
540
ISSN
0214-6282
Keywords
epigenetic, imprinting, preimplantation, reprogramming, germline
Repository Citation
Arney, Katharine L.; Erhardt, Sylvia; Drewell, Robert A.; and Surani, M. Azim, "Epigenetic reprogramming of the genome - From the germ line to the embryo and back again" (2001). Biology. 158.
https://commons.clarku.edu/faculty_biology/158
