Biology

Chromatin looping mediates boundary element promoter interactions

Document Type

Article

Abstract

One facet of the control of gene expression is long-range promoter regulation by distant enhancers. It is an important component of the regulation of genes that control metazoan development and has been appreciated for some time but the molecular mechanisms underlying this regulation have remained poorly understood. A recent study by Cleard and colleagues reports the first in vivo evidence of chromatin looping and boundary element promoter interaction. Specifically, they studied the function of a boundary element within the cis-regulatory region of the Abdominal-B (Abd-B) gene of Drosophila melanogaster. © 2006 Wiley Periodicals, Inc.

Publication Title

BioEssays

Publication Date

2007

Volume

29

Issue

1

First Page

7

Last Page

10

ISSN

0265-9247

DOI

10.1002/bies.20520

Keywords

Drosophila melanogaster

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