Dissecting the regulatory switches of development: Lessons from enhancer evolution in Drosophila

Authors

Matthew J. Borok, Harvey Mudd College
Diana A. Tran, Harvey Mudd College
Margaret C.W. Ho, Harvey Mudd College
Robert A. Drewell, Harvey Mudd CollegeFollow

Document Type

Article

Abstract

Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.

Publication Title

Development

Publication Date

1-1-2010

Volume

137

Issue

1

First Page

5

Last Page

13

ISSN

0950-1991

DOI

10.1242/dev.036160

Keywords

cis-regulatory modules, transcription factor

Repository Citation

Borok, Matthew J.; Tran, Diana A.; Ho, Margaret C.W.; and Drewell, Robert A., "Dissecting the regulatory switches of development: Lessons from enhancer evolution in Drosophila" (2010). Biology. 143.
https://commons.clarku.edu/faculty_biology/143