Biology
Document Type
Article
Abstract
The molecular control of gene expression in development is mediated through the activity of embryonic enhancer cis-regulatory modules. This activity is determined by the combination of repressor and activator transcription factors that bind at specific DNA sequences in the enhancer. A proposed mechanism to ensure a high fidelity of transcriptional output is functional redundancy between closely spaced binding sites within an enhancer. Here I show that at the bithorax complex in Drosophila there is selective redundancy for both repressor and activator factor binding sites in vivo. The absence of compensatory binding sites is responsible for two rare gain-of-function mutations in the complex. © 2011 Drewell.
Publication Title
G3: Genes, Genomes, Genetics
Publication Date
12-1-2011
Volume
1
Issue
7
First Page
603
Last Page
606
ISSN
2160-1836
DOI
10.1534/g3.111.001404
Keywords
Bithorax complex, ccis-regulation, DNA binding site, Drosophila, enhancer, transcription factor
Repository Citation
Drewell, Robert A., "Transcription factor binding site redundancy in embryonic enhancers of the drosophila bithorax complex" (2011). Biology. 138.
https://commons.clarku.edu/faculty_biology/138
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright Conditions
Must link to publisher version: https://doi.org/10.1534/g3.111.001404
