Chemistry

Potential role of annexin A7 in cancers

Document Type

Article

Abstract

Annexin A7 (Anxa7) is a member of the multigene annexin superfamily of Ca2+-regulated and phospholipid-binding proteins. Accumulated evidence indicates that the deregulation, loss of heterozygosity (LOH) and subcellular localization of Anxa7 are associated with the occurrence, invasion, metastasis and progression of a variety of cancers. Anxa7 appears to have a tumor-suppression role in glioblastoma, glioblastoma multiforme (GBM), melanoma and prostate cancer (CaP) but, controversially and interestingly, Anxa7 also appears to promote the development and malignancies of liver cancer, gastric cancer (GC), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC) and breast cancer (BC). The associations between Anxa7 and malignant tumors as well as potential mechanisms of action are summarized and discussed in current review. Anxa7 has potential for use as a biomarker for the diagnosis, treatment and prognosis of certain tumors. © 2013 Elsevier B.V.

Publication Title

Clinica Chimica Acta

Publication Date

8-3-2013

Volume

423

First Page

83

Last Page

89

ISSN

0009-8981

DOI

10.1016/j.cca.2013.04.018

Keywords

Annexin A7, function, malignancy, tumor

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