Chemistry
Document Type
Article
Abstract
The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer’s disease (AD). Both Aβ and tau self-assemble to form the two major pathological hallmarks of AD: amyloid plaques and neurofibrillary tangles, respectively. In this review, we show that naturally occurring polyphenols abundant in fruits, vegetables, red wine, and tea possess the ability to target pathways associated with the formation of assemblies of Aβ and tau. Polyphenols modulate the enzymatic processing of the amyloid-β precursor protein and inhibit toxic Aβ oligomerization by enhancing the clearance of Aβ42 monomer, modulating monomer–monomer interactions and remodeling oligomers to non-toxic forms. Additionally, polyphenols modulate tau hyperphosphorylation and inhibit tau β-sheet formation. The anti-Aβ-self-assembly and anti-tau-self-assembly effects of polyphenols increase their potential as preventive or therapeutic agents against AD, a complex disease that involves many pathological mechanisms.
Publication Title
Molecules
Publication Date
2019
Volume
24
Issue
12
ISSN
1420-3049
DOI
10.3390/molecules24122316
Keywords
Alzheimer's disease 0, amyloid assemblies, amyloid-β self-assembly, neurofibrillary tangles, Polyphenols, Tau hyperphosphorylation, Tau self-assembly
Repository Citation
Zheng, Qiuchen; Kebede, Micheal T.; Kemeh, Merc M.; Islam, Saadman; Lee, Bethany; Bleck, Stuart D.; Wurfl, Liliana A.; and Lazo, Noel D., "Inhibition of the self-assembly of Aβ and of tau by polyphenols: Mechanistic studies" (2019). Chemistry. 124.
https://commons.clarku.edu/chemistry/124
Cross Post Location
Student Publications
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Conditions
Zheng, Q., Kebede, M. T., Kemeh, M. M., Islam, S., Lee, B., Bleck, S. D., ... & Lazo, N. D. (2019). Inhibition of the self-assembly of Aβ and of tau by polyphenols: Mechanistic studies. Molecules, 24(12), 2316.
