Chemistry

ACTB in cancer

Document Type

Article

Abstract

Beta-actin (ACTB) has traditionally been regarded as an endogenous housekeeping gene and has been widely used as a reference gene/protein in quantifying expression levels in tumors. However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. ACTB is generally found to be up-regulated in the majority of tumor cells and tissues. The abnormal expression and polymerization of ACTB and the resulting changes to the cytoskeleton are revealed to be associated with the invasiveness and metastasis of cancers. The current review explores relevant mechanisms, integrates current understandings, and provides suggestions for future studies of the roles of ACTB in tumors. © 2012.

Publication Title

Clinica Chimica Acta

Publication Date

2-8-2013

Volume

417

First Page

39

Last Page

44

ISSN

0009-8981

DOI

10.1016/j.cca.2012.12.012

Keywords

ACTB, cancer, function, tumor

Share

COinS