Chemistry
ACTB in cancer
Document Type
Article
Abstract
Beta-actin (ACTB) has traditionally been regarded as an endogenous housekeeping gene and has been widely used as a reference gene/protein in quantifying expression levels in tumors. However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. ACTB is generally found to be up-regulated in the majority of tumor cells and tissues. The abnormal expression and polymerization of ACTB and the resulting changes to the cytoskeleton are revealed to be associated with the invasiveness and metastasis of cancers. The current review explores relevant mechanisms, integrates current understandings, and provides suggestions for future studies of the roles of ACTB in tumors. © 2012.
Publication Title
Clinica Chimica Acta
Publication Date
2-8-2013
Volume
417
First Page
39
Last Page
44
ISSN
0009-8981
DOI
10.1016/j.cca.2012.12.012
Keywords
ACTB, cancer, function, tumor
Repository Citation
Guo, Chunmei; Liu, Shuqing; Wang, Jiasheng; Sun, Ming Zhong; and Greenaway, Frederick T., "ACTB in cancer" (2013). Chemistry. 170.
https://commons.clarku.edu/chemistry/170