Chemistry
Document Type
Article
Abstract
Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca2+-dependent membrane-binding annexin proteins. It participates in membrane and cytoskeleton organization, cholesterol homeostasis, membrane trafficking, cell adhesion and signal transduction. The expression levels of AnxA6 are closely associated with melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer, prostate cancer, acute lymphoblastic leukemia, chronic myeloid leukemia, large-cell lymphoma and myeloma. AnxA6 exhibits dual functions in cancer, acting either as a tumor suppressor or promoter, depending on the type of cancer and the degree of malignancy. In several types of cancer, AnxA6 acts via Ras, Ras/MAPK and/or FAK/PI3K signaling pathways by mainly mediating PKCα, p120GAP, Bcr-Abl and YY1. In the present review, the roles of AnxA6 in different types of cancer are summarized.
Publication Title
Oncology Letters
Publication Date
10-2015
Volume
10
Issue
4
First Page
1947
Last Page
1952
ISSN
1792-1074
DOI
10.3892/ol.2015.3498
Keywords
Annexin A6, biomarker, cancer, malignancy, tumor promoter, tumor suppressor
Repository Citation
Qi, Houbao; Liu, Shuqing; Guo, Chunmei; Wang, Jiasheng; Greenaway, Frederick T.; and Sun, Ming Zhong, "Role of annexin A6 in cancer (Review)" (2015). Chemistry. 164.
https://commons.clarku.edu/chemistry/164
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Conditions
Qi, H., Liu, S., Guo, C., Wang, J., Greenaway, F. T., & Sun, M. Z. (2015). Role of annexin A6 in cancer. Oncology letters, 10(4), 1947-1952. https://doi.org/10.3892/ol.2015.3498. https://doi.org/10.3892/ol.2015.3498
